Anticancer activity of some novel thieno [2, 3-d] pyrimidine derivatives.

According to WHO population-based data, cancer is a leading cause of mortality worldwide accounting for almost 13% of all death [1]. Among all types of cancer, lung, breast, colorectal, stomach, and prostate cancer is the underlying cause for the majority of cancer death. Hitherto, chemotherapy remains one of the therapeutic strategies adopted worldwide for the management of cancer either alone or in conjunction with surgery and/or radiotherapy. Currently in clinical use anticancer agents suffer from a number of drawbacks correlated to drugs’ associated side effects and/or tumors’ multi-drug resistance [2,3]. Hence, it obviously is still of interest to search for new bioactive molecules having anticancer activity. Thiophenes and thienopyrimidines have been reported to possess interesting biological and pharmacological activities where several derivatives are used as antibacterial [1-3], antiinflammatory [4], anticancer [5,6], and antiviral agents [7].